The regular CPython installer on Windows installs the py launcher and associates it with .py files. The py launcher supports shebang lines.
This was covered in a blog post about this same topic that was posted here a few days ago. According to that you have to omit the -S: https://thisdavej.com/share-python-scripts-like-a-pro-uv-and...
https://news.ycombinator.com/item?id=43500124
I haven't tried it myself, I simply changed the file association so all .py files are opened with uv run as standard.
https://docs.python.org/3/using/windows.html#python-launcher...
Interesting. The workflow I've been using skips the CPython installer and only uses uv.
Windows doesn't support shebang lines as you probably know, but if you associate uv with .py files you'll get the same result.
I think it should be something like this:
ftype Python.File=C:\Path\to\uv.exe run %L %*
assoc .py=Python.File