Windows doesn't support shebang lines as you probably know, but if you associate uv with .py files you'll get the same result.

I think it should be something like this:

  ftype Python.File=C:\Path\to\uv.exe run %L %*

If you don't use the CPython installer the Python.File file type might not be defined, so you might need to set that with `assoc` first:

  assoc .py=Python.File