I got around this with Pillow and Python by reducing the image quality to like 20% which in my case didn't have any compromises, but reduced the image size quite substantially. Then I repackaged the images back into cbz and used KCC to make a proper file. As a disclaimer, I have done it only with the Kaiji Ultimate Survivor series to be able to fit the entire manga on my Kindle PW3 with 4GB of storage (I already used up like 1.5GB). Kaiji has less complex drawings, which most certainly plays a role.