It depends on how much platform specific stuff you are trying to use. Also in 2025 most packages are tailored for the operating system by packagers - not the original authors.
Autotools is going to check every config from the past 50 years.
>Also in 2025 most packages are tailored for the operating system by packagers - not the original authors.
No? Most operating systems don't have a separate packager. They have the developer package the application.
Yes? Each operating system is very different and almost every package has patches or separate install scripts.