One could say that it also raised awareness of Ghibli movies to people who didn't know them (and I know quite a few who never heard of him). So I'm not sure it's all black. On a different angle, it shows how silly humanity is and thirsty for models has become - and let's all now make Ghibli pictures because it's cool is just the latest tiktok dance, performed by some who claimed they'd never dance on tiktok.
I think it does change things by how you are introduced to things and what parts of culture you associate it with.
I have the upmost respect for Bill Waterson for not merchandizing Calvin and Hobbes and the cultural memory of the work is better for it imo.