"mostly" for sure; it's a good mental model and allows me to build modular applications etc, but I hate that a nontrivial amount of code and headspace is spent on things like re-renders, memoization, useCallback, dependency arrays, etc. I hope the React compiler will finally solve this, because the competition (apparently?) has (I haven't had the time to look into e.g. vue yet).
Absolutely, it would be nice if we found the right abstraction to get rid of that part as well. Basically every non-React framework's answer to that is Signals (aka change tracking), where React is doubling down on unidirectional data flow and thus dependency arrays. React Compiler indeed solves the 99% of performance related memo-s.
For effects you still will have to understand the mental model (which I'd argue is inherent in the domain and not incidental to the tech).
From reading Nue's docs on Interactivity, it seems to opt-out of the discussion by going back to good old manual UI refreshs. I personally would not choose that, too many pre-React debugging nights spent on chasing state<->UI desynchronization bugs.