I have little experience with kernel modules. ZFS is the only one I have long term experience with on Debian.

The only issue I've had with the kernel module aspect is VPS configuration, I use Linode and they used to automatically set everything to use the hypervisor kernel, but the kernel module is obviously built against the versions installed on your OS and these will probably be different.

All you have to do is make sure the boot configuration is set to use GRUB if using a VPS. Linode seem to have switched to this by default for Debian now.