You know, I have really tried to like TeXmacs, and I just can't. It's kind of cool, but it really feels like an amateur product to me. The UI is hard to navigate, everything feels kind of clunky. The documents it produces look nice, so it's not "bad" or anything, but I found it kind of awkward to use.

As it stands, the compromise that I do is write Markdown and render it to LaTeX or XeLaTeX with Pandoc. Not claiming it's the "best" or anything, but the documents look nice to me and Markdown is easy to write.