A huge focus of gene drive manipulation of mosquitos is to force their populations to extinction.

The male is created with an X chromosome that will destroy any other X with which it is paired, leaving only other male progeny with the hostile X.

This goes on for a few hundred generations, driving the female population to zero.

There are grave moral questions in this, but eventually the technology will reach those who decide to deploy it, perhaps against the general will. It is only a matter of time.