For Chrome's PDF renderer, the runtime is V8, so we're literally one (hilarious) line of code away from this glorious future existing today:

https://pdfium.googlesource.com/pdfium/+/refs/heads/main/fpd...

> // Use interpreted JS only to avoid RWX pages in our address space. Also, --jitless implies --no-expose-wasm, which reduce exposure since no PDF should contain web assembly.

> return "--jitless";