> The HN title makes it sound like differences between the brain and ANNs were previously unknown and is misleading IMO
There are no words in the title which express this. Your own brain is "making it sound" like that. Misleading, yes, but attribute it correctly.
"differs fundamentally", being in the tense that it is, with the widely known context that AI is "modeled after the brain", definitely does suggest that oh no, they got the brain wrong when that modelling happened, therefore AI is fundamentally built wrong. Or at least I can definitely see this angle in it.
The angle I actually see in it though is the typical pitiful appeal to the idea that the brain is this incredible thing we should never hope to unravel, that AI bad, and that everyone working on AI is an idiot as per the link (and then the link painting a leaps and bounds more nuanced picture).
The title does express that, due to context. An article in Nature with the title "X is Y" suggests that, until now, we didn't know that X is Y, or we even thought that X is definitely not Y.