Added fructose seems bad for you. Specifically, a high ratio of fructose:glucose (which doesn't occur in nature) does something weird to your metabolism. Your gut uses some hack like detecting only glucose to trigger intermediate steps in the metabolism of both, and consumption of high fructose:glucose foods causes weight gain.
High fructose:glucose ratios definitely exist in nature.
Agave syrup is 4:1. Apples and pears are around 2:1.
Moreover, high fructose corn syrup is a bit of a misnomer. Most HFCS used in food are 42% fructose, 58% glucose. The ones used in soda are typically 55:45.
That makes even the latter's ratio lower than say, watermelon, papaya, pears, apples, mango, blackberries, etc.