> Is it the case that there exists some pathological UTM S, such that K(s|S) (the Kolmogorov complexity of s relative to S) is arbitrarily small

Yes. It’s not even that hard to create. Just take a standard UTM and perform a branching “if” statement to check if the input is the string of interest before executing any other instructions.

> Is there some way of defining a meta-complexity measure, the complexity of some UTM without a reference UTM?

Haha, not that anyone knows of. This is one of the issues with Solomonoff induction as well. Which UTM do we pick to make our predictions? If no UTM is privileged over any other, then some will necessarily give very bad predictions. Averaged over all possible induction problems, no single UTM can be said to be superior to the others either. Solomonoff wrote an interesting article about this predicament a while ago.

(A lot of people will point to the constant offset of Kolmogorov complexity due to choice of UTM as though it somehow trivializes the issue. It does not. That constant is not like the constant in time complexity which is usually safe to ignore. In the case of Solomonoff induction, it totally changes the probability distribution over possible outcomes.)